Synthesis and Biological Applications of Certain 1-acetamido-(benzothiazol-2'-yl)-5-aryltetrazole and Benzothiazol- 2'-yl-1-ethylamine-5-aryltetrazoles
نویسنده
چکیده
A new series of 1-acetamido-(benzothiazol-2'-yl)-5-aryltetrazole and Benzothiazol-2'-yl-1-ethylamine-5aryltetrazole were synthesized by [3+2] cycloaddition reaction of an organic azide with organic nitriles. The chemical structures of the synthesized compounds were confirmed by IR, H NMR, mass spectral and elemental analysis. The compounds were screened for antibacterial, antifungal and analgesic activity. The results showed significant antifungal activity against Aspergillus niger and Candida albicans at 250 ìg/ ml comparable to that of standard (ketokonazole). The analgesic activity of 1-acetamido-(benzothiazol-2'-yl)5-benzyl-tetrazole and Benzothiazol-2'-yl-1-ethylamine-5-benzyltetrazole was found to equivalent of diclofenac by acetic acid induced writhing method at the dose of 100mg/Kg.
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